Lake Manyara usually works best as a compact stop on a Northern Circuit safari, especially when connecting Arusha, Tarangire, Ngorongoro and Karatu.
Many travellers visit Lake Manyara because it adds a completely different mood to a Northern Circuit safari. Instead of big open plains, the park brings groundwater forest, primates, lake scenery, birdlife and the possibility of activities beyond the vehicle.
Lake Manyara works especially well when staying in or near Karatu, or when building a shorter route that includes Ngorongoro and Tarangire. It is not usually the main wildlife anchor of a safari, but it adds variety and helps break up the route.